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"If we can better understand how Hsp70 influences tTG, we can find ways to modulate that
interaction to immobilize cancer cells and keep
them from becoming invasive," said Dr. Cerione.
Meanwhile his lab discovered another more insidious way cancer propagates: by sending surprise packages that turn normal cells cancerous.
Dr. Cerione's lab demonstrated the parcels' cancercausing powers, described how they are made, and
revealed a way to jam production. Treatments that
follow suit could slow tumor growth and metastasis.
Remote recruiting through an inter-cellular mail
system allows cancer cells to grow their ranks without having to move. While most cells communicate
through substances that stimulate growth and hormones, cancer cells and stem cells use microvesicles,
which are stuffed with unconventional cargo that
boosts the survival and growth rates of recipient cells
and can completely change their form and function.
"Even if we immobilize cancer cells, as long
as they can make these microvesicles they can
continue spreading cancer," said Dr. Cerione.
"Treatments targeting the microvesicle production pathway we've outlined could have
a real impact on slowing cancer progression."
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